Perennial plants are more likely to be medicinal plants than annuals. Lupine was chosen as an example here because of its specific name. It fills the bill for a plant used in medicine because it's showy, common and perennial. But these days, common may not mean what it once did. It is estimated that 90% of lupines have disappeared. Their habitat of dry open ground is perfectly suited for human habitation. So maybe it's a good thing we don't use them for medicine these days. Besides, they didn't really work. These lupines have been recorded in AL, CT, DE, FL, GA, IA(T), IL, IN, KY, LA, MA, MD(T), ME(X), MI, MN, MS, NC, NH(T), NJ, NY, OH, PA(R), RI(S), SC, TX, VA, VT(E), WI, WV, NF, and ON. Ives Fen Preserve, Lenawee Co MI, 5/23/11.