This Indian-tobacco really has been smoked, but it's unclear just how much it was used. It is a medicinal plant in use from ancient times until 1993, when the FDA banned it. It has genuine effects for combating addictions, including nicotine. The problem is the side effects, which reliably include almost any awful reaction you can imagine, even death. Makes it a bit of a hard sell as something that will make you feel better. So, it was smoked, but how many used it more than once? These flowers are about 3/8 inch, appearing in mid-summer and continuing til fall. Indian-tobacco grows in AL, AR, CT DE, GA, IA, IL, IN, KS, KY, LA, MA, MD, ME, MI, MN, MO, MS, NC, NE, NH, NJ, NY, OH, PA, RI, SC, TN, VA, VT, WI, WV, BC, NB, NS, ON, PE, and QC. Monroe Co MI, 8/25/13.